Lipid Phase Behavior and Protein-Lipid Interactions within Nanolipoprotein Particles upon Sol-Gel Derived Encapsulation

Analysis of Lipid Phase Behavior and Protein Conformational Changes in Nanolipoprotein Particles upon Entrapment in Sol–Gel-Derived Silica

The entrapment of nanolipoprotein particles (NLPs) and liposomes in transparent, nanoporous silica gel derived from the precursor tetramethylorthosilicate was investigated. NLPs are discoidal patches of lipid bilayer that are belted by amphiphilic scaffold proteins and have an average thickness of 5 nm. The NLPs in this work had a diameter of roughly 15 nm and utilized membrane scaffold protein...

Aqueous Sol-Gel Process for Protein Encapsulation

Porous silica materials made by low-temperature sol-gel process are promising host matrixes for encapsulation of biomolecules. To date, researchers have focused on sol-gel routes using alkoxides such as tetramethyl orthosilicate (TMOS) and tetraethyl orthosilicate (TEOS) for encapsulation of biomolecules. These routes lead to formation of alcohol as a byproduct that can have a detrimental effec...

Phase behavior of pure lipid bilayers with mismatch interactions.

Lipid-protein interactions.

Intrinsic membrane proteins are solvated by a shell of lipid molecules interacting with the membrane-penetrating surface of the protein; these lipid molecules are referred to as annular lipids. Lipid molecules are also found bound between transmembrane α-helices; these are referred to as non-annular lipids. Annular lipid binding constants depend on fatty acyl chain length, but the dependence is...

Protein-Lipid Interactions - ReadingSample

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